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These biosimilar products can be approved only for indications which are previously approved for the reference biological product by authorized regulatory bodies. The degree of AFL and liver fibrosis can be determined by ultrasonography, transient elastography, MRI, measurement of serum biomarkers and liver biopsy histology. Mildly elevated serum ferritin is a common feature of NAFLD that does not necessarily indicate hepatic iron overload, though it can impact disease progression. Nonalcoholic fatty liver disease is now recognized as the most common liver disease in the United States, with a prevalence of approximately 5% in the general population and up to 25% to 75% in patients with obesity and type II diabetes mellitus. If prophylaxis can be used effectively to protect an expatriate and his family for decades why should the same approach not be used to protect at risk groups in the local population? In view of the efficacy of chemoprophylaxis in protecting non-immunes, it is surprising that so little attention has been given to the use of drugs to protect the local population. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences?.
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